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An Animal Model of Hearing Loss From -Difluoromethylornithine

Cornelius Jansen, MD; Douglas E. Mattox, MD; Kenneth D. Miller, MD; William E. Brownell, PhD

Arch Otolaryngol Head Neck Surg. 1989;115(10):1234-1237.

Abstract
• -Difluoromethylornithine is a new antineoplastic and antiparasitic drug that inhibits the synthesis of polyamines. It causes a sensorineural hearing loss in humans. We have established an animal model for -difluoromethylornithine-induced hearing loss. The time course for onset and recovery of the hearing loss in animals was similar to that seen in humans. Electrophysiologic and histologic data suggest that the anatomic site of -difluoromethylornithine-induced hearing loss is the organ of Corti. Unlike other drugs with ototoxic effects, the specific enzymatic site of action of -difluoromethylornithine is known, making it a potentially important tool in auditory research.

(Arch Otolaryngol Head Neck Surg. 1989;115:1234-1237)

Author Affiliations
From the Department of Otolaryngology–Head and Neck Surgery, The Johns Hopkins Hospital, Baltimore, Md (Drs Jansen, Mattox, and Brownell), and the Department of Medicine, Georgetown University, Washington, DC (Dr Miller).

Footnotes
Accepted for publication May 30, 1989.

Reprint requests to Department of Otolaryngology-Head and Neck Surgery, The Johns Hopkins Hospital, 600 N Wolfe St, Baltimore, MD 21204 (Dr Mattox).

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