This Article  • References  • Full text PDF  • Reply to article  • Send to a friend  • Save in My Folder  • Save to citation manager  • Permissions  Citing Articles  • Citation map  • Citing articles on HighWire  • Contact me when this article is cited  Related Content  • Similar articles in this journal  Social Bookmarking   What's this?

Shigehiro Ueyama, MD; Hideyuki Kawauchi, MD; Goro Mogi, MD

Arch Otolaryngol Head Neck Surg. 1988;114(8):878-882.

Abstract
• Effects of mucosa-derived T-suppressor cells on induction of IgG-mediated otitis media with effusion (OME) were investigated in mice, since antigenantibody reactions in the tympanic cavity are pathogenic mechanisms of OME. Splenic T-suppressor cells from strain C₃H/HeN female mice, to which ovalbumin (OVA) had been orally administered, were transferred intravenously to syngeneic mice. The mice receiving the T-suppressor cells were immunized with OVA intraperitoneally and then injected with OVA into the tympanic cavity. Nine of ten control mice, to which splenic T cells from saline-fed mice were administered, developed OME, while OME was seen in only one of ten mice receiving splenic T cells from OVA-fed mice. The results show that IgG-mediated OME can be suppressed to a certain extent by the induction of antigen-specific, mucosa-derived, T-suppressor cells.

(Arch Otolaryngol Head Neck Surg 1988;114:878-882)

Author Affiliations
From the Department of Otolaryngology, Medical College of Oita (Japan).

Footnotes
Accepted for publication March 14, 1988.

Reprint requests to Department of Otolaryngology, Medical College of Oita, 1-1506, Idaigaoka, Hazama-cho, Oita 879-56, Japan (Dr Mogi).

CiteULike    Connotea    Del.icio.us    Digg    Reddit    Technorati    Twitter     What's this?

THIS ARTICLE HAS BEEN CITED BY OTHER ARTICLES

Oral Vaccine Therapy for Pneumococcal Otitis Media in an Animal Model
Yoshimura et al.
Arch Otolaryngol Head Neck Surg 1991;117:889-894.
ABSTRACT