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Allan L. Abramson, MD; Milton Waner, MD; Janet Brandsma, PhD

Arch Otolaryngol Head Neck Surg. 1988;114(7):795-800.

Abstract
• Photodynamic activation of hematoporphyrin derivative was originally developed for the treatment of cancer. This article demonstrates that it may also be an effective therapy for papillomavirus infections of the larynx. Seventy-two hours prior to surgery, hematoporphyrin derivative (6 mg/kg) was given intravenously to two patients with the adultonset form of this disease. Three days later, endoscopic surgery was performed and 32 J cm² was delivered to the endolarynx via an argon pump dye laser with a red light output of 630 nm. No significant complications such as swelling or hemorrhage occurred. At follow-up (13 months) there has been no recurrence of the laryngeal papilloma in either of these patients. The surgical technique, molecular biology, and clinical implications of this work to control laryngeal papillomatosis are described.

(Arch Otolaryngol Head Neck Surg 1988;114:795-800)

Author Affiliations
From the Department of Otolaryngology and Communicative Disorders, Long Island Jewish Medical Center, NY (Drs Abramson and Brandsma), and Division of Otolaryngology, University of Sydney (Australia) and Royal Prince Alfred Hospital, Sydney, Australia (Dr Waner).

Footnotes
Accepted for publication March 14, 1988.

Reprint requests to Department of Otolaryngology and Communicative Disorders, Long Island Jewish Medical Center, New Hyde Park, NY 11042 (Dr Abramson).

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