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Alfred D. Heggie, MD; Yao-Shi Fu, MD

Arch Otolaryngol Head Neck Surg. 1988;114(7):788-790.

Abstract
• In previous studies, carcinoma of the uterine cervix of the mouse was induced by repeated vaginal exposure to inactivated herpes simplex viruses, type 1 or 2. To determine if the mouse nasopharynx is also susceptible to the carcinogenic effects of these viruses, animals were inoculated intranasally with suspensions of formaldehyde-inactivated herpes simplex viruses, type 1 or 2, or control material, four to five times a week. After exposure periods of 12, 20, and 32 weeks, groups of animals were killed randomly and the nasopharynx, along with the larynx, trachea, bronchi, and lungs, were examined histologically. No preinvasive or invasive lesions were detected. These data suggest that the nasopharynx and cervix of the mouse differ in susceptibility to induction of carcinogenesis by inactivated herpes simplex viruses.

(Arch Otolaryngol Head Neck Surg 1988;114:788-790)

Author Affiliations
From the Departments of Pediatrics (Dr Heggie) and Pathology (Dr Fu), Case Western Reserve University, Cleveland, and University Hospitals of Cleveland.

Footnotes
Accepted for publication March 28, 1988.

Reprints not available.

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