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Itzhak Brook, MD, MSc

Arch Otolaryngol Head Neck Surg. 1988;114(6):667-670.

Abstract
• The emergence and persistence of aerobic and anaerobic β-lactamase—producing bacteria (BLPB) were investigated in 26 children treated with penicillin for otitis media or pharyngitis and in 28 nontreated control children. β-Lactamase—producers were isolated in three (12%) of the treated children before therapy, in 12 (46%) seven to ten days after completion of therapy, in nine (35%) 40 to 45 days after therapy, and in seven (27%) 85 to 90 days after therapy. These organisms were present in three (11%) of the nontreated children, and the number of patients harboring BLPB stayed constant throughout the three-month follow-up. The predominant BLPB were Bacteroides species (Bacteroides melaninogenicus group, Bacteroides oralis, and Bacteroides orisbuccae), Staphylococcus aureus, Haemophilus influenzae, and Branhamella catarrhalis. The emergence and persistence of BLPB after penicillin therapy may have important implications for the antimicrobial management of infections of the upper respiratory tract.

(Arch Otolaryngol Head Neck Surg 1988;114:667-670)

Author Affiliations
From the Departments of Pediatrics and Surgery, Uniformed Services University of the Health Sciences, Bethesda, Md.

Footnotes
Accepted for publication March 14, 1988.

The opinions and assertions contained herein are the private ones of the writers and are not to be construed as official or as reflecting the views of the Navy Department or the Naval service at large.

Reprint requests to Armed Forces Radiobiology Research Institute, Bethesda, MD 20814-5145 (Dr Brook).

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