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Steven M. Parnes, MD; Zorik Spektor, MD; Norman Strominger, PhD

Arch Otolaryngol Head Neck Surg. 1988;114(6):653-656.

Abstract
• In the auditory/vestibular system, intravenous lidocaine hydrochloride administration has been reported to provide transient relief from severe tinnitus, reduce dizziness and emesis accompanying Meniere's disease, and sometimes improve audiometric thresholds in sensorineural hearing loss. In this study, the labyrinth was destroyed unilaterally in a series of cats. Animals constantly fell and demonstrated prominent contralateral nystagmus and a rotary motion of the head. Within four hours of a 4-mg/kg intravenous lidocaine hydrochloride injection, the cats were able to ambulate freely without falling. The nystagmus was reduced, and there was virtual absence of the rotary head motion. In contrast, the controls had persistent signs of vestibular disturbance. These results demonstrate that lidocaine infusion ameliorates the effects of unilateral labyrinthectomy in cats and thus may be a potential antivertiginous agent.

(Arch Otolaryngol Head Neck Surg 1988;114:653-656)

Author Affiliations
From the Division of Otolaryngology (Drs Parnes and Spektor) and Department of Anatomy (Dr Strominger), Albany (NY) Medical College.

Footnotes
Accepted for publication Aug 26, 1987.

Read before the 89th Annual Meeting of the American Laryngological, Rhinological, and Otological Society, Palm Beach, Fla, May 7, 1986.

Reprint requests to Division of Otolaryngology, Albany Medical College, Albany, NY 12208 (Dr Parnes).

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