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Transtympanic Iontophoresis of Dexamethasone and Fosfomycin
Hiroaki Sato, MD;
Haruo Takahashi, MD;
Iwao Honjo, MD
Arch Otolaryngol Head Neck Surg. 1988;114(5):531-533.
Abstract
• The effects of transtympanic iontophoresis of corticosteroids and antibiotics on otitis media with effusion (OME) were investigated. An experimental study using guinea pigs revealed that transtympanic passage of dexamethasone sodium phosphate and fosfomycin sodium by iontophoresis had sufficient anti-inflammatory and antimicrobial effects. Twenty children with OME (33 ears) who were treated by iontophoresis were compared with 28 untreated children with OME (35 ears) with respect to improvement assessed by tympanoaudiometry. After one month, tympanoaudiometry revealed improvement in 21 (63.6%) of the treated ears but in only 13 (37.1%) of the untreated ears, indicating the efficacy of this treatment for OME.
(Arch Otolaryngol Head Neck Surg 1988;114:531-533)
Author Affiliations
From the Department of Otolaryngology, Kyoto (Japan) University (Drs Sato and Honjo); and the Division of Otolaryngology, Kobe City (Japan) General Hospital (Dr Takahashi).
Footnotes
Accepted for publication Jan 11, 1988.
Reprint requests to the Department of Otolaryngology, Faculty of Medicine, Kyoto University, Sakyo-ku, Kyoto 606, Japan (Dr Sato).
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