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Dov Ophir, MD; Aaron Fink, MD, PhD; Abraham Eliraz, MD; Elvan Tabachnik, MD; Zvi Bentwich, MD

Arch Otolaryngol Head Neck Surg. 1988;114(5):522-524.

Abstract
• The relationship between release of leukotriene C₄ (LTC₄) from nasal mucosa in vivo and from peripheral blood leukocytes (PBLs) in vitro was examined in 18 patients with untreated rhinitis allergic to the house dust mite, Dermatophagoides pteronyssinus, and in 20 nonallergic control subjects following challenge with the specific allergen. Allergic patients were subjected to intranasal and PBL challenge with D pteronyssinus and a nonrelevant allergen, Artemisia vulgaris. In all allergic patients, intranasal challenge by D pteronyssinus, but not by A vulgaris, resulted in a release of substances from the nasal mucosa that reacted in a radioimmunoassay with antiserum to LTC₄. Dermatophagoides pteronyssinus challenge in vitro of

Author Affiliations
From the Department of Otolaryngology (Dr Ophir), Ruth Ben-Ari Institute of Clinical Immunology (Drs Fink and Bentwich), Pulmonary Unit (Dr Eliraz), and Department of Pediatrics "B" (Dr Tabachnik), Kaplan Hospital, Rehovot, Israel (affiliated with the Medical School of the Hebrew University and Hadassah, Jerusalem).

Footnotes
Accepted for publication Oct 20, 1987.

Reprint requests to Department of Otolaryngology, Kaplan Hospital, 76100 Rehovot, Israel (Dr Ophir).

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