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A Flow Cytometric DNA Analysis

Adel K. El-Naggar, MD, PhD; John G. Batsakis, MD; Mario A. Luna, MD; Robert C. Hickey, MD

Arch Otolaryngol Head Neck Surg. 1988;114(5):520-521.

Abstract
• Twenty-five Hürthle cell tumors of the thyroid gland, histopathologically classified into three groups—adenomas, carcinomas, and indeterminant—have been studied by DNA flow cytometry using archived, paraffin-embedded tissues. Tumor ploidy characteristics were correlated with patient follow-up and survival with the conclusions that (1) nuclear DNA ploidy alone does not distinguish benign from malignant Hürthle cell tumors; (2) diploid DNA Hürthle cell carcinomas behave far less aggressively than aneuploid Hürthle cell carcinomas; and (3) all patients with aneuploid carcinomas died of their disease or are alive with persistent carcinoma.

(Arch Otolaryngol Head Neck Surg 1988;114:520-521)

Author Affiliations
From the Department of Anatomic Pathology, Division of Pathology (Drs El-Naggar, Batsakis, and Luna), and the Department of General Surgery, Division of Surgery (Dr Hickey), The University of Texas System Cancer Center, M. D. Anderson Hospital and Tumor Institute, Houston.

Footnotes
Accepted for publication Feb 8, 1988.

Reprint requests to Department of Pathology, The University of Texas System Cancer Center, M. D. Anderson Hospital and Tumor Institute, 1515 Holcombe Blvd, Houston, TX 77030 (Dr Batsakis).

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