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Robert Colebunders, MD; Henry Francis, MD; Jonathan M. Mann, MD, MPH; Kapita M. Bila, MD; Kandi Kandi, MD, PhD; Izaley Lebughe, MD; Paul Gigase, MD; Erik Van Marck, MD; Abe M. Macher, MD; Thomas C. Quinn, MD; James W. Curran, MD; Peter Piot, MD, PhD

Arch Otolaryngol Head Neck Surg. 1988;114(3):330-332.

Abstract
• In Europe and in the United States, bilateral parotid gland swelling has been observed as a sign of human immunodeficiency virus (HIV) infection in children, but it has not been associated with HIV infection in adults. We observed a chronic parotid gland swelling in nine HIV-seropositive patients during a nine-month period in Kinshasa, Zaire. Parotid gland enlargement was bilateral in seven patients (78%), slightly painful in seven patients (78%), and painless in two patients (22%). No evidence of inflammation was observed around Stensen's duct. One of the two patients in whom a parotid gland biopsy was performed had a malignant lymphoma of the large-cell, histiocytic type. In the other patient, the parotid gland showed normal morphology with minor inflammation. Among 284 adults and 40 children with symptomatic HIV infection, chronic parotid gland enlargement was observed in none of the patients. However, two (0.7%) of the adults presented with an acute pyogenic parotitis. Further studies are needed to determine whether parotid gland enlargement is associated with HIV infection.

(Arch Otolaryngol Head Neck Surg 1988;114:330-332)

Author Affiliations
From Project Syndrome d'ImmunoDeficit Acquit, Department of Public Health, Kinshasa, Zaire (Drs Colebunders, Francis, Mann, and Lebughe); Belgian-Zairian Medical Cooperation Kinshasa (Dr Colebunders); Laboratory of Immunoregulation, National Institute of Allergy and Infectious Diseases, National Institutes of Health, Bethesda, Md (Drs Francis and Quinn); Acquired Immunodeficiency Syndrome Program, Center for Infectious Diseases, Centers for Disease Control, Atlanta (Drs Mann and Curran); Mama Yemo Hospital, Kinshasa (Dr Bila); Ser-; vice of Stomatology, University Clinics of Kinshasa (Dr Kandi); Institute of Tropical Medicine, Antwerp, Belgium (Drs Colebunders, Gigase, Van Marck, and Piot); and Registry of Acquired Immunodeficiency Disease Pathology, Department of Infectious and Parasitic Disease Pathology, Armed Forces Institute of Pathology, Washington, DC (Dr Macher).

Footnotes
Accepted for publication May 20, 1987.

Reprint requests to Department of Microbiology, Institute of Tropical Medicine, Nationalestaat 155, 2000 Antwerp, Belgium (Dr Colebunders).

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