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Evaluation of Single-Dose Cefazolin Prophylaxis for Toxic Shock Syndrome
Jay A. Jacobson, MD;
Michael H. Stevens, MD;
Evelyn M. Kasworm, MT (ASCP)
Arch Otolaryngol Head Neck Surg. 1988;114(3):326-327.
Abstract
• Otolaryngologists have increased their use of parenteral prophylactic antibiotics to prevent toxic shock syndrome following nasal surgery. This rare but potentially serious postoperative complication presumably requires nasal carriage of a toxigenic strain of Staphylococcus aureus by a susceptible patient. We investigated the effect of a single preoperative dose of intravenous cefazolin on nasal carriage of S aureus. Thirty patients were studied; 15 were S aureus carriers initially and 12 (80%) remained culture positive after prophylaxis and at the time surgery was completed. We conclude that this particular regimen is unlikely to have a major effect on the incidence of toxic shock syndrome following nasal surgery.
(Arch Otolaryngol Head Neck Surg 1988;114:326-327)
Author Affiliations
From the Divisions of Infectious Disease (Dr Jacobson and Ms Kasworm) and Otorhinolaryngology (Dr Stevens), LDS Hospital and University of Utah School of Medicine, Salt Lake City.
Footnotes
Accepted for publication Nov 23, 1987.
Reprint requests to Division of Infectious Disease, LDS Hospital, Eighth Avenue and C Street, Salt Lake City, UT 84143 (Dr Jacobson).
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THIS ARTICLE HAS BEEN CITED BY OTHER ARTICLES
Toxic Shock Syndrome: Associated with Nasal Packing
Mansfield and Peterson
CLIN PEDIATR 1989;28:443-445.
Evaluation of Single-Dose Cefazolin Prophylaxis for Toxic Shock Syndrome
POOLE
Arch Otolaryngol Head Neck Surg 1989;115:248-248.
ABSTRACT
Toxic Shock Syndrome
KENNEDY
Arch Otolaryngol Head Neck Surg 1988;114:1477-1478.
ABSTRACT
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