This Article  • References  • Full text PDF  • Reply to article  • Send to a friend  • Save in My Folder  • Save to citation manager  • Permissions  Citing Articles  • Citation map  • Citing articles on HighWire  • Contact me when this article is cited  Related Content  • Similar articles in this journal  Social Bookmarking   What's this?

David J. Kessler, MD; Robert A. Mickel, MD, PhD; Alan Lichtenstein, MD

Arch Otolaryngol Head Neck Surg. 1988;114(3):313-318.

Abstract
• Natural killer (NK) cells are a subpopulation of lymphocytes involved in host defense against tumor cells. Although a great deal of clinical research has focused on the role of NK cells in the blood of patients with cancer, very little has been done to determine what role they may play at the regional or lymph node level. One hundred seven lymph nodes from 22 patients with head and neck cancer and eight control patients were assayed for NK cell cytotoxicity against the human erythroleukemia cell line K562. Six of these nodes contained a discrete intracapsular focus of metastatic tumor. Lymphocytes from these focally positive nodes exhibited a significant depression of NK cell cytotoxicity compared with all other nodes. These data suggest that the presence of metastatic tumor inhibits NK cell function at the regional level in patients with head and neck squamous cell carcinoma.

(Arch Otolaryngol Head Neck Surg 1988;114:313-318)

Author Affiliations
From the Division of Head and Neck Surgery (Drs Kessler and Mickel) and the Department of Medicine (Dr Lichtenstein), UCLA Medical Center; and the West Los Angeles (Calif) Veterans Administration Medical Center, the Veterans Administration Medical Center Cancer Center, Los Angeles, and the Jonnson Comprehensive Cancer Center, Los Angeles (Drs Mickel and Lichtenstein).

Footnotes
Accepted for publication Nov 13, 1987.

Reprint requests to the Division of Head and Neck Surgery (W112C), West Los Angeles Veterans Administration Medical Center, Wilshire and Sawtelle Boulevards, Los Angeles, CA 90073 (Dr Mickel).

CiteULike    Connotea    Del.icio.us    Digg    Reddit    Technorati    Twitter     What's this?

THIS ARTICLE HAS BEEN CITED BY OTHER ARTICLES

Cure of an Established Nonimmunogenic Tumor, SCC VII, With a Novel Interleukin 12-Based Immunotherapy Regimen in C3H Mice
Mandpe et al.
Arch Otolaryngol Head Neck Surg 2003;129:786-792.
ABSTRACT | FULL TEXT  

Inhibition of Lymphocyte Function by Head and Neck Carcinoma Cell Line Soluble Factors
Bailet et al.
Arch Otolaryngol Head Neck Surg 1997;123:855-862.
ABSTRACT  

Interleukin-8 Expression by Head and Neck Squamous Cell Carcinoma
Cohen et al.
Arch Otolaryngol Head Neck Surg 1995;121:202-209.
ABSTRACT  

Functional and Phenotypic Analysis of Lymphocytes in Head and Neck Cancer
Snyderman et al.
Arch Otolaryngol Head Neck Surg 1991;117:899-905.
ABSTRACT  

Production of Lymphokine-Activated Lymphocytes: Lysis of Human Head and Neck Squamous Cell Carcinoma Cell Lines
Alessi et al.
Arch Otolaryngol Head Neck Surg 1989;115:725-730.
ABSTRACT