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For Acute Otitis Media in the Chinchilla Model

Kenny H. Chan, MD; J. Douglas Swarts; William J. Doyle, PhD; Kunchitthape Tanpowpong, MD; David R. Kardatzke

Arch Otolaryngol Head Neck Surg. 1988;114(11):1266-1269.

Abstract
• The efficacy of an investigational macrolide, azithromycin, in the treatment of acute otitis media consequent to an infection by a strain of β-lactamase– producing Haemophilus influenzae, was evaluated using the chinchilla animal model. The results indicate that the azithromycin high-dosage (30 mg/kg/d) group has a significantly higher rate for effusion sterilization and resolution as compared with the other treatment groups. Unique pharmacokinetic properties of this investigational antimicrobial were demonstrated. Clinical trials using azithromycin for the treatment of upper respiratory tract infections, including otitis media, are warranted.

(Arch Otolaryngol Head Neck Surg 1988;114:1266-1269)

Author Affiliations
From the Department of Otolaryngology, Children's Hospital of Pittsburgh (Drs Chan, Doyle, and Tanpowpong, and Mr Swarts), and Department of Biostatistics, Graduate School of Public Health, University of Pittsburgh (Mr Kardatzke).

Footnotes
Accepted for publication Aug 12, 1988.

Reprint requests to Department of Pediatric Otolaryngology, Children's Hospital of Pittsburgh, One Children's Place, 3705 Fifth Ave at DeSoto street, Pittsburgh, PA 15213 (Dr Chan).

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