This Article  • References  • Full text PDF  • Reply to article  • Send to a friend  • Save in My Folder  • Save to citation manager  • Permissions  Citing Articles  • Citation map  • Contact me when this article is cited  Related Content  • Similar articles in this journal  Social Bookmarking   What's this?

Michael E. Glasscock, III, MD; C. Gary Jackson, MD; Glenn W. Knox, MD

Arch Otolaryngol Head Neck Surg. 1988;114(11):1252-1255.

Abstract
• Materials commonly employed in the preparation of otologic homografts such as ethanol and formaldehyde are effective in vitro in inactivating human immunodeficiency virus (HIV). However, to our knowledge, the complete permeation of homograft materials with preservative has not been demonstrated. Ethanol and formaldehyde have not been shown to be effective in inactivating the CreutzfeldtJakob agent. The literature on sterilization procedures for these agents is reviewed. Standard procedures for preparation of otologic homografts are examined. It is recommended that donor HIV serologic status be determined when otologic homografts must be used. Further research is required to determine the efficacy of otologic homograft sterilization techniques against HIV and CreutzfeldtJakob disease.

(Arch Otolaryngol Head Neck Surg 1988;114:1252-1255)

Author Affiliations
From The Otology Group (Drs Glasscock and Jackson) and the Department of Otolaryngology, Vanderbilt University School of Medicine (Dr Knox), Nashville.

Footnotes
Accepted for publication Aug 12, 1988.

Presented in part at the Triological Southern Section Meeting, Birmingham, Ala, Jan 16, 1988.

Reprint requests to The Otology Group, 1811 State St, Nashville, TN 37203 (Dr Glasscock).

CiteULike    Connotea    Del.icio.us    Digg    Reddit    Technorati    Twitter     What's this?