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Chromosomal Analysis of Recurrent Laryngeal Papillomas
Ann-Leslie Zaslav, MS;
Bettie M. Steinberg, PhD;
Judith Stamberg, PhD;
Yue J. Lin, PhD;
Alan L. Abramson, MD
Arch Otolaryngol Head Neck Surg. 1988;114(10):1170-1174.
Abstract
• Recurrent laryngeal papillomas are tumors believed to be induced by human papillomaviruses. Severity of this disease varies due to the unpredictability of clinical remissions and recurrences. However, the severity of the disease does not affect the classification of these tumors as benign, and the rate of spontaneous conversion of recurrent laryngeal papillomas to carcinomas is very low. Laryngeal papillomas from six patients were evaluated cytogenetically after short-term culture. All six specimens were chromosomally normal, consistent with their classification as benign tumors with a low rate of malignant conversion. The presence of human papillomaviruses has no detectable effect on the chromosomes of these tumors.
(Arch Otolaryngol Head Neck Surg 1988;114:1170-1174)
Author Affiliations
From the Department of Biological Sciences, St John's University, Jamaica, NY (Ms Zaslav and Dr Lin); Division of Human Genetics, Schneider Children's Hospital (Ms Zaslav and Dr Stamberg); and Department of Otolaryngology (Drs Steinberg and Abramson), Long Island Jewish Medical Center, New Hyde Park, NY.
Footnotes
Accepted for publication June 14, 1988.
Reprint requests to Department of Biological Sciences, St John's University, Jamaica, NY 11439 (Dr Lin).
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