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Miro Makek, MD; Douglas E. Mattox, MD; Stephen Schmid, MD; Ugo Fisch, MD

Arch Otolaryngol Head Neck Surg. 1988;114(10):1127-1130.

Abstract
• Thirty-three synthetic middle ear prostheses removed after two to 99 months of implantation were examined histologically. All prostheses were infiltrated by fibroblasts, capillaries, collagen fibrils, and multinucleate foreign body giant cells. Although some of the giant cells contained tiny particles of the prosthetic material, there was no evidence of erosion or engulfment of larger particles of the prosthesis or structural dissolution of the prosthesis. New histologic findings were aseptic necrosis and focal calcification in the interior of some of the prostheses.

(Arch Otolaryngol Head Neck Surg 1988;114:1127-1130)

Author Affiliations
From the Institute of Pathology (Dr Makek) and the Department of Otolaryngology (Drs Schmid and Fisch), University Hospital, Zurich, and the Department of Otolaryngology–Head and Neck Surgery, The Johns Hopkins Hospital, Baltimore (Dr Mattox).

Footnotes
Accepted for publication May 23, 1988.

Reprint requests to Institute of Pathology, University Hospital, Schmelzbergstrasse 12, CH 8091 Zurich, Switzerland (Dr Makek).

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