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John W. Georgitis, MD; Danny Shen, PhD

Arch Otolaryngol Head Neck Surg. 1988;114(1):63-67.

Abstract
• This study evaluated the relationship between brompheniramine maleate and changes in nasal reactivity. Ten subjects with moderate-to-severe perennial rhinitis took brompheniramine for seven days using either a standard formulation or sustained-release preparation. Nasal aerodynamics and response to histamine were assessed at the end of the week. Despite varying doses of brompheniramine maleate (12 to 32 mg/d), there was no significant difference in nasal reactivity to histamine or in changes of nasal airflow, indicating that low doses of brompheniramine are highly effective in blocking histamine₁ receptors in the nasal mucosa.

(Arch Otolaryngol Head Neck Surg 1988;114:63-67)

Author Affiliations
From the Section of Allergy and Clinical Immunology, Department of Pediatrics, Bowman Gray School of Medicine of Wake Forest University, Winston-Salem, NC (Dr Georgitis), and the Department of Pharmaceutics, School of Pharmacy, University of Washington, Seattle (Dr Shen).

Footnotes
Accepted for publication Aug 31, 1987.

Read in part before the American Academy of Allergy and Immunology, New York, March 20, 1985.

Reprint requests to Department of Pediatrics, Bowman Gray School of Medicine of Wake Forest University, Winston-Salem, NC 27103 (Dr Georgitis).

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