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Ototoxicity of Vasocidin Drops Applied to the Chinchilla Middle Ear
Orval E. Brown, MD;
Charles G. Wright, PhD;
Masami Masaki, MD;
William L. Meyerhoff, MD, PhD
Arch Otolaryngol Head Neck Surg. 1988;114(1):56-59.
Abstract
• Some widely used ototopical preparations are potentially toxic to the middle and inner ear. Vasocidin Ophthalmic Solution (sulfacetamide sodium and prednisolone sodium phosphate) has been advocated as an alternative agent that may have fewer toxic side effects in the treatment of otorrhea. Vasocidin was introduced into the bullae of nine chinchillas to investigate the effects on the middle and inner ear. The organ of Corti and stria vascularis were found to be entirely normal in 17 of the 18 temporal bones studied. Changes observed in the middle ears at one week included inflammation, hemorrhage, and effusion. Examination of specimens at four weeks revealed resolution of most of the inflammatory changes. The results of this experimental study indicate that Vasocidin causes reversible middle ear inflammation with little or no toxic effect on inner ear structures.
(Arch Otolaryngol Head Neck Surg 1988;114:56-59)
Author Affiliations
From the Department of Otorhinolaryngology, University of Texas Health Science Center, Dallas.
Footnotes
Accepted for publication July 18, 1987.
Read before the Fourth International Symposium on Recent Advances in Otitis Media, Bal Harbour, Fla, June 4, 1987.
Reprint requests to Department of Otorhinolaryngology, University of Texas Health Science Center, 5323 Harry Hines Blvd, Dallas, TX 75235 (Dr Brown).
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