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Randal S. Weber, MD; Edward J. Shillitoe, BDS, PhD; K. Thomas Robbins, MD; Mario A. Luna, MD; John G. Batsakis, MD; Donald T. Donovan, MD; Karen Adler-Storthz, PhD

Arch Otolaryngol Head Neck Surg. 1988;114(1):23-26.

Abstract
• Human papillomaviruses (HPVs) have been associated with both benign and malignant neoplasms of the head and neck. To determine the prevalence and types of HPVs in this neoplasm, we examined fixed tissue from 21 patients by in situ hybridization. Human papillomavirus types 6b and 11 probes were used, and hybridization was positive to both types in lesions from 16 (76%) of 21 patients. Hybridization to the HPV-11 probe resulted in the most intense nuclear staining throughout the epithelium, probably indicating a high copy number. The high incidence of viral DNA sequences found in this tumor suggests a potential etiologic role. Therapeutic implications are briefly discussed.

(Arch Otolaryngol Head Neck Surg 1988;114:23-26)

Author Affiliations
From the Departments of Head and Neck Surgery (Drs Weber and Robbins) and Pathology (Drs Luna and Batsakis), The University of Texas M. D. Anderson Hospital and Tumor Institute at Houston, the Department of Microbiology, The University of Texas Dental Branch (Drs Shillitoe and Storthz), and the Department of Otorhinolaryngology, Baylor College of Medicine (Dr Donovan), Houston.

Footnotes
Accepted for publication Sept 10, 1987.

Reprint requests to Department of Microbiology, The University of Texas Dental Branch, PO Box 20068, Houston, TX 77225 (Dr AdlerStorthz).

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