This Article  • References  • Full text PDF  • Reply to article  • Send to a friend  • Save in My Folder  • Save to citation manager  • Permissions  Citing Articles  • Citation map  • Citing articles on HighWire  • Contact me when this article is cited  Related Content  • Similar articles in this journal  Social Bookmarking   What's this?

Comparison of Monotherapy vs Combination Therapy

Burt R. Meyers, MD; Meryl H. Mendelson, MD; Simon C. Parisier, MD; Shalom Z. Hirschman, MD

Arch Otolaryngol Head Neck Surg. 1987;113(9):974-978.

Abstract
• Twenty patients with adult-onset diabetes mellitus and malignant external otitis (MEO) were treated at the Mount Sinai Medical Center, New York, over a seven-year period (August 1976 to October 1983). A retrospective analysis compared patients who received an antipseudomonal cephalosporin as monotherapy (group A) with those who received conventional antipseudomonal therapy (group B). Pseudomonas aeruginosa was isolated in all patients. Differences (group B > group A) included insulin dependence, underlying vascular disease, total number of cranial nerve palsies or paresis, and surgical procedures. The overall clinical outcome was similar in both groups; 64% of patients in group A (7/11) and 70% in group B (7/10) were cured at a follow-up period of five to 57 months. A more favorable outcome was found in patients with less extensive infection in both groups. Monotherapy compared favorably with conventional antipseudomonal therapy for the treatment of patients with MEO and moderate infection.

(Arch Otolaryngol Head Neck Surg 1987;113:974-978)

Author Affiliations
From the Division of Infectious Diseases, Department of Medicine (Drs Meyers, Mendelson, and Hirschman), and the Department of Otolaryngology (Dr Parisier), Mount Sinai School of Medicine, New York. Dr Parisier is now with the Manhattan Eye, Ear, and Throat Hospital, New York.

Footnotes
Accepted for publication April 17, 1987.

Reprint requests to Division of Infectious Diseases, Box 1090, Mount Sinai Medical Center, One Gustave L. Levy Pl, New York, NY 10029 (Dr Meyers).

CiteULike    Connotea    Del.icio.us    Digg    Reddit    Technorati    Twitter     What's this?

THIS ARTICLE HAS BEEN CITED BY OTHER ARTICLES

Adjuvant Hyperbaric Oxygen in Malignant External Otitis
Davis et al.
Arch Otolaryngol Head Neck Surg 1992;118:89-93.
ABSTRACT  

Hyperbaric Oxygenation for Necrotizing (Malignant) Otitis Externa
Shupak et al.
Arch Otolaryngol Head Neck Surg 1989;115:1470-1475.
ABSTRACT  

Efficacy of Oral Ciprofloxacin Plus Rifampin for Treatment of Malignant External Otitis
Rubin et al.
Arch Otolaryngol Head Neck Surg 1989;115:1063-1069.
ABSTRACT