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Michael F. Pratt, MD; James R. Schneider, MD; Frank R. Galey, PhD

Arch Otolaryngol Head Neck Surg. 1987;113(9):953-958.

Abstract
• Arterial allografts, 3.5 cm in length, were freeze-dried and placed into the femoral arteries of 20 female rabbits (16 experimental subjects and four controls). Immediate patency was 100%. Subjects were surgically explored after two months of observation. Overall patency at this time was 31% (5/16). A patency rate of 50% (5/10) was achieved with size-matched femoral grafts. However, all of the smaller diameter brachial grafts were unsuccessful. Analysis by light microscopy as well as transmission and scanning electron microscopy demonstrated intimal hyperplasia, which was more prominent in nonpatent grafts. There was no evidence of a cellular immune response to the freeze-dried grafts by the host. The use of size-matched grafts and postoperative anticoagulants in future studies may improve patency rates and the potential clinical applicability of this promising microvascular technique.

(Arch Otolaryngol Head Neck Surg 1987;113:953-958)

Author Affiliations
From the Departments of Otolaryngology (Dr Pratt), Orthopedics (Dr Schneider), and Clinical Investigation, Naval Hospital, San Diego, and the House Ear Institute, Los Angeles (Dr Galey).

Footnotes
Accepted for publication June 4, 1987.

The opinions or assertions expressed herein are those of the authors and are not to be construed as official or as reflecting the views of the Navy Department or the naval service at large.

Reprint requests to Clinical Investigation Department, Naval Hospital, San Diego, CA 92134-5000 (Dr Pratt).

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