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Experimental Study

Allan L. Abramson, MD; Nestor X. Barrezueta; Mark J. Shikowitz, MD

Arch Otolaryngol Head Neck Surg. 1987;113(8):854-858.

Abstract
• Whether cell death in carcinoma of the larynx during photodynamic therapy is due to singlet oxygen formation or mild hyperthermia is not resolved. When various experimental tumors were previously heated within the range of 41°C to 43°C, selective destruction was found. A canine model was used by placing a thermocouple probe into the vocal cord and then varying the total energy (10 to 150 J/cm ²), using a 630-nm dye laser; a temperature rise of only 0.5°C to 2.1°C was found. Thus, the thermal effects generated within the larynx (final temperature, 34.9°C to 37.1°C) should be insufficient to act alone in achieving a therapeutic response in either tumor tissue or destruction of normal epithelium.

(Arch Otolaryngol Head Neck Surg 1987;113:854-858)

Author Affiliations
From the Department of Otolaryngology and Communicative Disorders, Long Island Jewish Medical Center, New Hyde Park, NY.

Footnotes
Accepted for publication Feb 2, 1987.

Reprint requests to Department of Otolaryngology and Communicative Disorders, Long Island Jewish Medical Center, New Hyde Park, NY 11042 (Dr Abramson).

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