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First Observations on Humans

Thierry Vuillemin, MD, DMD; Joram Raveh, MD, DMD; Hermann Stich, HDMD; Hans Cottier, MD; BYRON J. BAILEY, MD

Arch Otolaryngol Head Neck Surg. 1987;113(8):836-840.

Abstract
• BIOCEM is a recently developed material that consists of bisphenol-a-glycidyl methacrylate ("epoxide methacrylate") as the organic matrix and pentacalcium hydroxide triphosphate ("tricalcium phosphate") with or without bioceramic A₂ as the filling particles. Previous animal experimentation has demonstrated that BIOCEM can establish and maintain direct contact with bone without compromising tissue vitality. Rather, it favors with time the ingrowth of, and coverage by, newly formed bone, thus creating interdigitations and strong fixation of the implant. This novel technique has now, for the first time, successfully been applied in humans, ie, for the fixation of frontal sinuses. Clinical, radiological, and histological findings are briefly reported, and it is also shown that the frontal sinus mucosa had recovered at the inside of the lesions filled with BIOCEM.

(Arch Otolaryngol Head Neck Surg 1987;113:836-840)

Author Affiliations
Chief Editor

From the Division of Maxillofacial Surgery, Department of Otolaryngology (Drs Vuillemin and Raveh), and the Departments of Dental Medicine (Dr Stich) and Pathology (Dr Cottier), University of Bern (Switzerland) Medical School.

Footnotes
Accepted for publication March 2, 1987.

Reprint requests to Division of Maxillofacial Surgery, Department of Otolaryngology, University of Berne, Inselspital, CH-3010 Bern, Switzerland (Dr Vuillemin).

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