 |
|
Evaluation of Poorly Differentiated Head and Neck NeoplasmsImmunocytochemistry Techniques
Elliot Abemayor, MD, PhD;
David J. Kessler, MD;
Paul H. Ward, MD;
Yao-S Fu, MD
Arch Otolaryngol Head Neck Surg. 1987;113(5):506-509.
Abstract
| |
• Despite the use of strict morphologic criteria, some head and neck neoplasms remain classified as "poorly differentiated" or "undifferentiated." To circumvent this diagnostic quandary, newer techniques primarily based on immunocytochemistry are being utilized to study tumor specimens. These methods rely on the binding of specific antibodies to cellular antigens in order to better define the tumor according to cell type. We treated six patients in whom a definitive pathologic diagnosis could not be obtained without the use of immunohistologic stains. In each case, the definition of a specific tumor category altered patient management. The approach to the evaluation of patients with undifferentiated head and neck neoplasms is important. Close cooperation between the clinician and pathologist is necessary in such cases; this is assisted by a knowledge of the uses and limitations of the current diagnostic modalities being used, as well as proper tissue handling and processing.
(Arch Otolaryngol Head Neck Surg 1987;113:506-509)
Author Affiliations
From the Division of Head and Neck Surgery (Drs Abemayor, Kessler, and Ward) and the Department of Pathology (Dr Fu), UCLA School of Medicine, Los Angeles.
Footnotes
Accepted for publication Nov 21, 1986.
Reprint requests to Division of Head and Neck Surgery, UCLA Medical Center, 10833 LeConte Ave, Los Angeles, CA 90024 (Dr Ward).
 CiteULike  Connotea  Del.icio.us  Digg  Reddit  Technorati  Twitter
What's this?
THIS ARTICLE HAS BEEN CITED BY OTHER ARTICLES
Granulocytic Sarcomas of the Head and Neck
Alessi et al.
Arch Otolaryngol Head Neck Surg 1988;114:1467-1470.
ABSTRACT
|
