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Lowell L. Williams, MD; Howard W. Lowery, MD; Barry T. Shannon, PhD

Arch Otolaryngol Head Neck Surg. 1987;113(4):397-400.

Abstract
• Aspects of humoral and cell-mediated immunity that might characterize the continuation of symptoms in 25 patients with chronic Meniere's disease were examined. We found significant elevations of both humoral and cellular immune responses to viral antigens of herpes simplex I, varicella-zoster, rubella, and cytomegalovirus. Serum immunoglobulins were quantitatively abnormal in 24 of 25 patients, without a consistent pattern. These immune responses may be linked to persistent viral infection in chronic Meniere's disease.

(Arch Otolaryngol Head Neck Surg 1987;113:397-400)

Author Affiliations
From the Departments of Pediatrics (Dr Williams), Otolaryngology (Dr Lowery), and Clinical Immunology (Dr Shannon), The Ohio State University College of Medicine, Columbus.

Footnotes
Accepted for publication Aug 26, 1986.

Reprint requests to 214 Ross Hall–Children's Hospital, 700 Children's Dr, Columbus, OH 43205 (Dr Williams).

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