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Brian S. Orisek, MD; Richard A. Chole, MD, PhD

Arch Otolaryngol Head Neck Surg. 1987;113(4):386-391.

Abstract
• Previous studies have shown that transmitted pressure may be an important factor in the induction of osteoclastic bone resorption by cholesteatoma. However, the ability of cholesteatomas to actually exert pressure on adjacent structures has not been studied. Implantable pressure gauges were used to measure static pressure exerted by induced gerbilline cholesteatomas. Cholesteatomas were found to exert pressures between 1.31 mm Hg and 11.88 mm Hg. Osteoclastic bone resorption was observed in areas where the pressure gauge transmitted these pressures to bone. Thus, pressure exerted by an expanding cholesteatoma may be an important factor in the induction of osteoclastic bone resorption.

(Arch Otolaryngol Head Neck Surg 1987;113:386-391)

Author Affiliations
From the Otology Laboratory, Department of Otolaryngology–Head and Neck Surgery, University of California, Davis.

Footnotes
Accepted for publication Sept 3, 1986.

Reprint requests to Department of Otolaryngology, University of California, Davis, Davis, CA 95616 (Dr Chole).

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