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Mark S. Brown, MD; Stephen P. Peters, MD; N. Franklin Adkinson, Jr, MD; David Proud, PhD; Anne Kagey-Sobotka, PhD; Philip S. Norman, MD; Lawrence M. Lichtenstein, MD; Robert M. Naclerio, MD

Arch Otolaryngol Head Neck Surg. 1987;113(2):179-183.

Abstract
• In order to assess the role of arachidonic acid metabolites in the early reaction to antigen, we challenged six allergic individuals with and without premedication with aspirin and recorded their clinical response, as indicated by number of sneezes, and measured the levels of inflammatory mediators. The early reaction to antigen was associated with increases in the levels of histamine, Na-tosyl-l-arginine methyl esterase (TAME-esterase) activity, prostaglandin (PG) D₂, leukotriene C₄, PGE, and thromboxane. Aspirin significantly inhibited the increases in the cyclooxygenase metabolites PGE, PGD₂, PGF₂, 6-keto-PGF₁, and thromboxane but did not affect the amount of sneezing or the levels of histamine, TAME-esterase activity, or leukotrienes. The pattern of the metabolites and their response to pretreatment with aspirin parallel the response of purified human lung mast cells, supporting the notion that the early phase of allergic rhinitis is a mast cell—dominated event.

(Arch Otolaryngol Head Neck Surg 1987;113:179-183)

Author Affiliations
From the Department of Otolaryngology—Head and Neck Surgery (Drs Brown and Naclerio), and the Department of Medicine, Division of Clinical Immunology (Drs Peters, Adkinson, Proud, Kagey-Sobotka, Norman, and Lichtenstein), The Johns Hopkins University School of Medicine, Baltimore.

Footnotes
Accepted for publication July 14, 1986.

Reprint requests to The Johns Hopkins University School of Medicine at the Good Samaritan Hospital, POB Suite 402, 5601 Loch Raven Blvd, Baltimore, MD 21239 (Dr Naclerio).

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