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Dov Ophir, MD

Arch Otolaryngol Head Neck Surg. 1987;113(2):155-159.

Abstract
• Antibodies to intermediate filaments and to desmoplakin were used to investigate the histogenetic origin of the olfactory neuroepithelium. Intermediate-filaments are tissue-specific molecular cytoskeletal markers; desmoplakin is the major desmosomal protein. The olfactory epithelia of eight human fetuses, aged 7 to 10 weeks (fertilization age) were immunofluorescently labeled with antibodies to the five classes of intermediate-filament proteins and to desmoplakin. Positive immunoreactivity to keratin and to desmoplakin was observed; both results indicate the epithelial nature of this tissue. The absence of neurofilaments and glialfibrillary acidic protein in the tissue containing sensory neurons and gliallike supporting cells is a unique feature, and may be related to the fact that olfactory neuroepithelium, like other epithelia, undergoes continuous turnover.

(Arch Otolaryngol Head Neck Surg 1987;113:155-159)

Author Affiliations
From the Department of Otolaryngology, Kaplan Hospital, Rehovot, Israel.

Footnotes
Accepted for publication Sept 3, 1986.

Read before the Second International Academic Conference on Immunobiology in Otology, Rhinology, and Laryngology, Utrecht, the Netherlands, Aug 26-29, 1986.

Reprint requests to Department of Otolaryngology, Kaplan Hospital, Rehovot 76100, Israel (Dr Ophir).

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