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Lanny Garth Close, MD; Dennis K. Burns, MD; Joan Reisch, PhD; Steven D. Schaefer, MD

Arch Otolaryngol Head Neck Surg. 1987;113(11):1191-1195.

Abstract
• The presence of squamous cell carcinoma within capillaries and/or venules in the immediate vicinity of primary lesions of the oral cavity and oropharynx may be related to regional lymph node metastasis. To evaluate this possibility, we have reviewed the clinical and histopathologic features of 43 consecutive cases of previously untreated T2 or greater squamous cell carcinoma of these sites managed with simultaneous surgical treatment of the primary neoplasm and the neck. The incidence of histologically proved cervical metastasis for all lesions with vascular invasion compared with those without vascular involvement was highly significant. No statistical correlation was found for the clinical stage of neck disease or for the other pathologic features of the primary tumor, ie, size, appearance, differentiation, depth of invasion, periphery of lesion, inflammatory infiltrate, and perineural invasion, when compared with the histopathologic status of regional lymph nodes.

(Arch Otolaryngol Head Neck Surg 1987;113:1191-1195)

Author Affiliations
From the Division of Head and Neck Surgery, Departments of Otorhinolaryngology (Drs Close and Schaefer) and Pathology (Dr Burns), and the Academic Computing Services (Dr Reisch), University of Texas Health Science Center, Dallas.

Footnotes
Accepted for publication June 17, 1987.

Read before the American Society for Head and Neck Surgery, Denver, April 28, 1987.

Reprint requests to Department of Otorhinolaryngology, University of Texas Health Science Center, 5323 Harry Hines Blvd, Dallas, TX 75235 (Dr Close).

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