 |
|
T-Cell Subsets and Natural Killer Cell Function With Squamous Cell Carcinoma of the Head and Neck
Marshall Strome, MD;
John R. Clark, MD;
Marvin P. Fried, MD;
Susan Rodliff;
Beverly A. Blazar, PhD
Arch Otolaryngol Head Neck Surg. 1987;113(10):1090-1093.
Abstract
• Twenty-two patients with squamous cell carcinoma of the head and neck were studied to assess potential abnormalities in total T lymphocytes, T4/T8 ratios, and natural killer cell function. Total T-cell counts were reduced for the entire group with the greatest reduction occurring in individuals with hypopharyngeal tumors and/or stage IV disease. Helper to suppressor ratios were within the norm for the total group, but specific site variances were detected in patients with oral cavity and hypopharyngeal primary carcinomas. Similarly altered T4/T8 ratios were noted with stage III disease. Substantive differences in natural killer cell activity were not observed. These data suggest that perturbations in T-lymphocyte subsets can be associated with decreased survival.
(Arch Otolaryngol Head Neck Surg 1987;113:1090-1093)
Author Affiliations
From the Departments of Otology and Laryngology and Surgery, Harvard Medical School and Brigham & Women's Hospital (Drs Strome and Fried); Dana Faber Cancer Center (Dr Clark and Ms Rodliff), Boston; and Wellsley (Mass) College (Dr Blazar).
Footnotes
Accepted for publication June 30, 1987.
Reprint requests to Joint Center for Otolaryngology, 333 Longwood Ave, Boston, MA 02115 (Dr Strome).
 CiteULike  Connotea  Del.icio.us  Digg  Reddit  Technorati  Twitter
What's this?
THIS ARTICLE HAS BEEN CITED BY OTHER ARTICLES
Clean-Contaminated Neck Surgery: Risk of Infection by Intrinsic and Extrinsic Factors.
Fusconi et al.
Arch Otolaryngol Head Neck Surg 2006;132:953-957.
ABSTRACT
| FULL TEXT
Natural Killer Cell Activity in Laryngeal Carcinoma
Gonzalez et al.
Arch Otolaryngol Head Neck Surg 1993;119:69-72.
ABSTRACT
|
