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Lymphocyte Subsets in Normal Airway Mucosa of the Human Nose
Birgit Winther, MD;
Donald J. Innes, Jr, MD;
Stacey E. Mills, MD;
Niels Mygind, MD;
Denise Zito;
Frederick G. Hayden, MD
Arch Otolaryngol Head Neck Surg. 1987;113(1):59-62.
Abstract
• The distribution and number of lymphocytes, monocytes/macrophages, and cells expressing HLA-DR antigen were studied in frozen biopsy sections of nasal mucosa from 40 healthy adults, using monoclonal antibody avidin-biotin immunoperoxidase techniques. The lymphocyte to monocyte/macrophage ratio was estimated to be 10:1; the T cell to B cell ratio was 3:1; and the T helper/inducer cell to T suppressor/cytotoxic cell ratio averaged 2.5:1. Regional differences were observed with a relatively increased number of T suppressor/cytotoxic cells around submucosal glands, and a relatively large number of B cells in lymphocyte aggregates in the lamina propria. The HLA-DR antigen was expressed in epithelial cells, suggesting involvement of surface epithelium of human airway in local immune responses.
(Arch Otolaryngol Head Neck Surg 1987;113:59-62)
Author Affiliations
From the Otopathological Laboratory, Department of Otorhinolaryngology, Rigshospitalet, University of Copenhagen (Drs Winther and Mygind); Departments of Otolaryngology, Head and Neck Surgery (Dr Winther), Pathology (Drs Innes, Mills, and Hayden, and Ms Zito), and Internal Medicine (Dr Hayden), University of Virginia School of Medicine, Charlottesville.
Footnotes
Accepted for publication June 10, 1986.
Reprint requests to Department of Otorhinolaryngology, Rigshospitalet, DK-2100 Copenhagen, Denmark (Dr Winther).
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