This Article  • References  • Full text PDF  • Reply to article  • Send to a friend  • Save in My Folder  • Save to citation manager  • Permissions  Citing Articles  • Citation map  • Citing articles on HighWire  • Contact me when this article is cited  Related Content  • Similar articles in this journal  Social Bookmarking   What's this?

Y. Christopher Chiu, MD; K. Brecht, MD; D. S. DasGupta, MD; E. Mhoon, MD

Arch Otolaryngol Head Neck Surg. 1986;112(9):988-990.

Abstract
• Cocaine, the active alkaloid in coca leaf, is widely used as local anesthetic for otolaryngologic procedures. Our patient suffered an acute nontransmural myocardial infarction following clinical use of cocaine as topical anesthesia for nasal surgery, the first such case to be documented, to our knowledge. Although evidence documenting its cardiovascular toxicity is listed in contemporary pharmacologic literature, clinical cardiac injury has been reported to date only with the recreational use of cocaine. Authentic documentation of drug composition when received through the intervention of illicit vendors is always difficult. The literature is reviewed, justifying the use of cocaine as the most popular topical anesthetic in otolaryngologic practice. However, we hope that awareness of this possible complication will create a resurgence of research interest in topical cocaine anesthesia.

(Arch Otolaryngol Head Neck Surg 1986;112:988-990)

Author Affiliations
From the Sections of Cardiology (Drs Chiu and DasGupta) and Otolaryngology-Head and Neck Surgery (Drs Brecht and Mhoon), University of Chicago Pritzker School of Medicine.

Footnotes
Accepted for publication Dec 4, 1985.

Reprint requests to University of Chicago Hospital and Clinics, 5841 S Maryland Ave, Hospital Box 283, Chicago, IL 60637 (Dr DasGupta).

CiteULike    Connotea    Del.icio.us    Digg    Reddit    Technorati    Twitter     What's this?

THIS ARTICLE HAS BEEN CITED BY OTHER ARTICLES

Cardiac Complication From Use of Cocaine and Phenylephrine in Nasal Septoplasty
Ashchi et al.
Arch Otolaryngol Head Neck Surg 1995;121:681-684.
ABSTRACT  

Cocaine-induced Myocardial Infarction in Patients with Normal Coronary Arteries
Minor et al.
ANN INTERN MED 1991;115:797-806.
ABSTRACT  

Potentiation of Cocaine-Induced Coronary Vasoconstriction by Beta-Adrenergic Blockade
Lange et al.
ANN INTERN MED 1990;112:897-903.
ABSTRACT  

Topical Cocaine Nasal Anesthesia
GORDON
Arch Otolaryngol Head Neck Surg 1987;113:211-211.
ABSTRACT