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Charlotte Jacobs, MD; Lawrence Weiss, MD; Richard T. Hoppe, MD

Arch Otolaryngol Head Neck Surg. 1986;112(6):654-658.

Abstract
• The results from 156 patients with extranodal head and neck lymphomas treated at Stanford (Calif) University School of Medicine are combined with the experience of other investigators to recommend the management of these lymphomas. The tonsil and sinuses were the most common sites of presentation, and the most common histology was diffuse histiocytic lymphoma. The histologic classification systems are described as well as the use of immunohistochemistry in diagnosis. The appropriate staging procedures and the Ann Arbor staging system are discussed. Following the staging of 948 patients, 66% were found to have stage I or stage II disease and 34% had more widespread disease. Treatment with radiotherapy is discussed. Patterns of relapse following local radiotherapy for 360 relapsing patients with stage I and II disease showed a 73% distal relapse rate. Various treatment programs are recommended based on site, stage, and histology.

(Arch Otolaryngol Head Neck Surg 1986;112:654-658)

Author Affiliations
From the Department of Medicine, Division of Oncology (Dr Jacobs), the Department of Pathology (Dr Weiss), and the Department of Radiation Therapy (Dr Hoppe), Stanford (Calif) University School of Medicine.

Footnotes
Accepted for publication Oct 25, 1985.

Reprint requests to Division of Oncology, M-211, Stanford University School of Medicine, Stanford, CA 94305 (Dr Jacobs).

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