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Michael D. McGinn, PhD; Richard A. Chole, MD, PhD; Steven P. Tinling, MA

Arch Otolaryngol Head Neck Surg. 1986;112(6):635-641.

Abstract
• The pressure produced by expanding aural cholesteatomas has been implicated as a causal factor in the induction of osteoclastic resorption of adjoining bone. This concept is supported by observations of osteoclastic bone resorption produced by expansive tympanic implants. We induced osteoclastic bone resorption in gerbils with tympanic implants of autologous and homologous cartilage, silicone rubber, and Teflon, which exerted pressure only by forces of gravity and surface tension. We estimated that the pressure exerted by these implants ranged from 2.1 x 10^–3 to 8.0 x 10^–3 dynes/sq cm (1.6 to 6.0 mm Hg). These pressures are within the range of pressures known to be exerted by cholesteatomas.

(Arch Otolaryngol Head Neck Surg 1986;112:635-641)

Author Affiliations
From the Department of Otorhinolaryngology, School of Medicine, University of California—Davis, Sacramento.

Footnotes
Accepted for publication Sept 6, 1985.

Reprint requests to Department of Otorhinolaryngology, University of California—Davis, 4301 X St, Suite 208, Sacramento, CA 95817 (Dr McGinn).

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