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Tatsuji Yamaguchi, MD; Thomas F. DeMaria, PhD; David J. Lim, MD

Arch Otolaryngol Head Neck Surg. 1986;112(5):554-557.

Abstract
• Because Haemophilus influenzae is one of the most common pathogens in otitis media with effusion, we have investigated the antibody response in the serum and middle ear effusion (MEE) in nontypable H influenzae–induced experimental acute otitis media in the chinchilla, using an enzyme-linked immunosorbent assay. During acute otitis media, a reasonable antibody titer was observed: local antibody titers in the MEEs were equal to or greater than those of the serum samples for four of five MEE samples obtained at one week after inoculation. By two weeks, titers in both serum and MEE samples were increased significantly. However, the bacteria persisted in the middle ear cavity, even in the presence of increasing antibody titers, for up to five weeks after infection. The reason for this persistence of the bacteria in the middle ear is unknown.

(Arch Otolaryngol Head Neck Surg 1986;112:554-557)

Author Affiliations
From the Otological Research Laboratories, Department of Otolaryngology, Ohio State University College of Medicine, Columbus. Dr Yamaguchi was on leave from the Department of Otolaryngology, Sapporo (Japan) Medical College.

Footnotes
Accepted for publication Sept 6, 1985.

Presented as a scientific exhibit at the Seventh Midwinter Research Meeting of the Association for Research in Otolaryngology, St Petersburg Beach, Fla, Feb 8, 1984.

Reprint requests to 4331 University Hospitals Clinic, 456 Clinic Dr, Columbus, OH 43210 (Dr DeMaria).

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