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Natural Killer Cell Response to Regional Lymph Node Metastases
Stimson P. Schantz, MD;
Louis Poisson, MS
Arch Otolaryngol Head Neck Surg. 1986;112(5):545-551.
Abstract
• A determination of natural killer cell activity was performed in 67 individuals with advanced head and neck cancer. The mean activity of 28 patients clinically staged T3 NO or T4 NO was 81 ± 11 lytic units (LU), significantly higher than 39 patients with palpable lymph node metastases (54 ± 5 LU). Assessing patients by extent of nodal disease revealed that activity actually increased, though not significantly, with progressive N-staging. A major determinate of increased natural killer cell cytotoxicity in patients with lymph node metastases was extranodal cancer within the neck. The mean activity of nine patients whose tumor was fixed to underlying structures or adherent to skin was 87 ± 15 LU, significantly higher than the 45 ± 4 LU mean value of the remaining patients with clinically determined regional nodal disease. The potential clinical implications of these findings are discussed.
(Arch Otolaryngol Head Neck Surg 1986;112:545-551)
Author Affiliations
From the Department of Head and Neck Surgery, M. D. Anderson Hospital and Tumor Institute, Houston.
Footnotes
Accepted for publication Sept 6, 1985.
Read before the fifth joint meeting of the American Society for Head and Neck Surgeons, Dorado, Puerto Rico, May 5, 1985.
Reprint requests to Department of Head and Neck Surgery, M. D. Anderson Hospital and Tumor Institute, 6723 Bertner Ave, Houston, TX 77030 (Dr Schantz).
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