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Gerald B. Brookes, FRCS

Arch Otolaryngol Head Neck Surg. 1986;112(5):536-540.

Abstract
• Sixty-six patients with Meniere's disease were studied for possible general immunologic abnormalities. The disease was bilateral in 20 cases, causing active symptoms in 49. Thirty-six healthy control subjects were also studied. Immune activity was assessed by quantitative measurement of the circulating immune complexes, serum immunoglobulin assay, and acetate electrophoresis, and by an auto-antibody screen to a battery of ten general tissue antigens. Thirty-six (54.5%) of the 66 patients with Meniere's disease were found to have significantly raised circulating immune complex levels compared with one (2.9%) of the 36 controls. A statistically significant increased incidence of autoantibodies was also found in the Meniere's group.

(Arch Otolaryngol Head Neck Surg 1986;112:536-540)

Author Affiliations
From the Department of Otolaryngology, The London Hospital.

Footnotes
Accepted for publication June 14, 1985.

Read before the British Otorhinolaryngological Research Society, London, Oct 5, 1984.

Reprint requests to The National Hospital for Nervous Diseases, Queen Square, London, England WC1X 8DA (Dr Brookes).

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