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Jacquelynne P. Corey, MD; David D. Caldarelli, MD; James C. Hutchinson, Jr, MD; Lauren D. Holinger, MD; Samuel G. Taylor, IV, MD; John L. Showel, MD; Judith A. Kooser, MD

Arch Otolaryngol Head Neck Surg. 1986;112(4):437-439.

Abstract
• We evaluated postoperative complications in a randomized series of patients with head and neck cancer who received preoperative chemotherapy. Forty-two patients with advanced squamous carcinoma of the head and neck were randomized to receive either high-dose metho-trexate with leucovorin calcium rescue (23 patients) or no chemotherapy (19 patients) prior to definitive conventional treatment. The two groups of patients were balanced by sex, disease site, stage, histologic grade, and prior therapy. Sixteen of the 23 patients receiving preoperative chemotherapy had postoperative complications, whereas only eight of 19 patients not receiving chemotherapy had postoperative complications. Surgical complications included wound infections, orocutaneous fistulas, and flap necrosis.

(Arch Otolaryngol Head Neck Surg 1986;112:437-439)

Author Affiliations
From the Department of Otolaryngology and Bronchoesophagology (Drs Corey, Caldarelli, Hutchinson, and Holinger), the Section of Medical Oncology, Department of Medicine (Drs Taylor and Showel), and the Department of Therapeutic Radiology (Dr Kooser), Rush Medical College, Rush-Presbyterian-St Luke's Medical Center, Chicago. Dr Corey is now with the Department of Otolaryngology-Head and Neck Surgery, West Virginia University Medical Center, Morgantown.

Footnotes
Accepted for publication July 22, 1985.

Read before the International Conference on Head and Neck Cancer, Baltimore, July 27, 1984.

Reprint requests to Department of Otolaryngology-Head and Neck Surgery, West Virginia University Medical Center, Morgantown, WV 26506 (Dr Corey).

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