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A Double-blind Randomized Trial of Cephalosporins in Head and Neck Surgery

Jonas T. Johnson, MD; Victor L. Yu, MD; Eugene N. Myers, MD; Robin L. Wagner; Barbara A. Sigler, RN, MNEd

Arch Otolaryngol Head Neck Surg. 1986;112(2):151-153.

Abstract
• Cefazolin and moxalactam were compared in a prospective randomized double-blind trial of 118 patients undergoing oncologic head and neck surgery. Both antibiotics were given 2 g every four hours for four doses. Five infections were encountered in the cefazolin group (8.5%) and two infections in the moxalactam group (3.4%); this difference was not statistically significant. This assessment does not indicate, however, that the two regimens are equally efficacious.

(Arch Otolaryngol Head Neck Surg 1986;112:151-153)

Author Affiliations
From the Department of Otolaryngology, Eye and Ear Hospital, University of Pittsburgh School of Medicine.

Footnotes
Accepted for publication July 12, 1985.

Reprint requests to Eye and Ear Hospital, 230 Lothrop St, Pittsburgh, PA 15213 (Dr Johnson).

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