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The Interaction of Noise and Aspirin in the Chick Basilar PapillaNoise and Aspirin Toxicity
Paul R. Lambert, MD;
Patricia E. Palmer;
Edwin W. Rubel, PhD
Arch Otolaryngol Head Neck Surg. 1986;112(10):1043-1049.
Abstract
• The possible synergism between noise and aspirin for causing cochlear damage was examined histologically. Six chicks fed aspirin for five days and five chicks fed a normal diet only were paired and placed in sound chambers. They were exposed to a 1500-Hz tone at 115 dB sound pressure level for eight hours. The mean serum salicylate level just before noise exposure was 24 mg/dL (1.74 mmol/L). Ten days later they were killed, and the temporal bones were processed. Hair cell counts were made at 100-µm intervals throughout the length of the basilar papilla (cochlea). The noise produced a discrete cochlear lesion centered about 30% of the distance from the base to apex. The addition of aspirin did not significantly alter the extent or location of this lesion. One aspirin-fed chick had a unilateral middle ear effusion, and a striking shift in the center of damage toward the apex was noted in this cochlea.
(Arch Otolaryngol Head Neck Surg 1986;112:1043-1049)
Author Affiliations
From the Department of Otolaryngology—Head and Neck Surgery, University of Virginia Medical School, Charlottesville.
Footnotes
Accepted for publication Feb 20, 1986.
Reprint requests to Department of Otolaryngology—Head and Neck Surgery, University of Virginia Medical School, Box 430, Charlottesville, VA 22908 (Dr Lambert).
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