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Osteoclast Stimulation by Positive Middle-Ear Air Pressure
David E. Wolfman, MD;
Richard A. Chole, MD, PhD
Arch Otolaryngol Head Neck Surg. 1986;112(10):1037-1042.
Abstract
• The mechanism of pathologic bone resorption associated with cholesteatoma is controversial. It is now evident that transmitted pressure is a significant factor in the activation of osteoclasts. Previous studies on the effect of pressure have been confounded by the possible foreign body effect of materials placed into the middle ear to induce the pressure. Positive air pressures were maintained in the middle ear of Mongolian gerbils via implanted Silastic catheters. Histologic evaluation of the ventral bulla wall was performed after pressure had been applied for two weeks. A significant increase in the number density, area density, and size of osteoclasts present in the pressurized bullae was noted at pressures of 4,6,10, and 20 mm Hg, but not at 2 mm Hg. We conclude that minute increases in pressure, in the absence of foreign objects, stimulate osteoclastic bone resorption in the middle ear of the gerbil.
(Arch Otolaryngol Head Neck Surg 1986;112:1037-1042)
Author Affiliations
From the Department of Otolaryngology—Head and Neck Surgery, University of California, Davis, Sacramento.
Footnotes
Accepted for publication Feb 11, 1986.
Reprint requests to Otology Research Laboratory, University of California, Davis, 1159 Surge III, Davis, CA 95616 (Dr Chole).
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