This Article  • References  • Full text PDF  • Reply to article  • Send to a friend  • Save in My Folder  • Save to citation manager  • Permissions  Citing Articles  • Citation map  • Citing articles on HighWire  • Contact me when this article is cited  Related Content  • Similar articles in this journal  Social Bookmarking   What's this?

Experimental Study

Mark J. Shikowitz, MD; Bettie M. Steinberg, PhD; Allan L. Abramson, MD

Arch Otolaryngol Head Neck Surg. 1986;112(1):42-46.

Abstract
• Hematoporphyrin derivative has been shown to selectively localize in malignant tissues and chemically induced animal papillomas. It is a powerful photosensitizing agent that can cause destruction and death of tissues in which it has localized by the generation of singlet oxygen when activated by light of the appropriate wavelength (photodynamic therapy [PDT]). Laryngeal papillomas are rapidly growing benign epithelial neoplasms with a clinical course marked by multiple recurrences after surgical removal. Before considering PDT as a therapeutic modality in the treatment of this debilitating disease we developed an animal model for experimentation. Using the cottontail rabbit papillomavirus, sometimes referred to as the Shope papillomavirus, large cutaneous papillomas were induced on the backs of Dutch Belted rabbits. Following intravenous administration of hematoporphyrin derivative, PDT was delivered with white light. Marked regression of the papillomas was noted with replacement by normal hair-bearing skin. The clinical implications of this work to the control of laryngeal papillomatosis is discussed.

(Arch Otolaryngol Head Neck Surg 986;112:42-46)

Author Affiliations
From the Department of Otolaryngology and Communicative Disorders, Long Island Jewish Medical Center, New Hyde Park, NY.

Footnotes
Accepted for publication July 5, 1985.

Reprint requests to Department of Otolaryngology and Communicative Disorders, Long Island Jewish Medical Center, New Hyde Park, NY 11042 (Dr Shikowitz).

CiteULike    Connotea    Del.icio.us    Digg    Reddit    Technorati    Twitter     What's this?

THIS ARTICLE HAS BEEN CITED BY OTHER ARTICLES

Clinical Trial of Photodynamic Therapy With Meso-Tetra (Hydroxyphenyl) Chlorin for Respiratory Papillomatosis
Shikowitz et al.
Arch Otolaryngol Head Neck Surg 2005;131:99-105.
ABSTRACT | FULL TEXT  

Photodynamic Therapy Using m-Tetra(Hydroxyphenyl) Chlorin: An Animal Model
Lofgren et al.
Arch Otolaryngol Head Neck Surg 1994;120:1355-1362.
ABSTRACT  

Variable Light-Dose Effect on Photodynamic Therapy for Laryngeal Papillomas
Abramson et al.
Arch Otolaryngol Head Neck Surg 1994;120:852-855.
ABSTRACT  

Clinical Effects of Photodynamic Therapy on Recurrent Laryngeal Papillomas
Abramson et al.
Arch Otolaryngol Head Neck Surg 1992;118:25-29.
ABSTRACT  

In Vitro Photodynamic Treatment of Normal and Human Papilloma Virus-Transfected Keratinocytes With Photofrin II and Red Light
Bernstein et al.
Arch Dermatol 1991;127:683-687.
ABSTRACT  

Photodynamic Therapy in the Treatment of Squamous Cell Carcinoma of the Head and Neck
Wenig et al.
Arch Otolaryngol Head Neck Surg 1990;116:1267-1270.
ABSTRACT  

Laser Photodynamic Therapy for Papilloma Viral Lesions
Go et al.
Arch Otolaryngol Head Neck Surg 1990;116:1177-1180.
ABSTRACT  

The Pathologic and Thermal Effects of Gold Vapor Laser Photodynamic Therapy on the Larynx: Experimental Study
Abramson et al.
Arch Otolaryngol Head Neck Surg 1990;116:687-691.
ABSTRACT  

Biodistribution of Indium 111-Labeled Dihematoporphyrin Ether in Papillomas and Body Tissues: Relevance to Photodynamic Therapy
Shikowitz et al.
Arch Otolaryngol Head Neck Surg 1989;115:845-847.
ABSTRACT  

The Clinical Treatment of Laryngeal Papillomas With Hematoporphyrin Therapy
Abramson et al.
Arch Otolaryngol Head Neck Surg 1988;114:795-800.
ABSTRACT  

Histological and Molecular Analysis of Cottontail Rabbit Papillomavirus-Induced Papillomas Treated With Hematoporphyrin Derivative Photodynamic Therapy
Shikowitz et al.
Arch Otolaryngol Head Neck Surg 1988;114:175-178.
ABSTRACT  

The Pathologic Effects of Photodynamic Therapy on the Larynx: Experimental Study
Abramson et al.
Arch Otolaryngol Head Neck Surg 1988;114:33-39.
ABSTRACT  

Thermal Effects of Photodynamic Therapy on the Larynx: Experimental Study
Abramson et al.
Arch Otolaryngol Head Neck Surg 1987;113:854-858.
ABSTRACT  

Porphyrin Sensitized Phototherapy
Berns and McCullough
Arch Dermatol 1986;122:871-874.
ABSTRACT