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David E. Schuller, MD; Debora H. Libby; John J. Rinehart, MD; George G. Milo, PhD; Antoinette Koolemans-Beynen, MS

Arch Otolaryngol. 1985;111(7):465-468.

Abstract
• The purpose of this study was to evaluate whether the interaction of human neck node lymphocytes with primary tumor cells could be modulated with the administration of bacillus Calmette-Guérin (BCG) or N-acetylmuramyldipeptide (MDP). The procedures involve the clonogenic assay applied towards studying the interactions of neck node lymphocytes with the tumor-stem cell population. It has been previously demonstrated that a dynamic interaction occurs between neck nodal lymphocytes and tumor. Bacillus Calmette-Guérin or MDP was incubated for three days with lymphocytes from neck nodes, after which the human squamous tumor cells from the patient were exposed continuously to the resulting lymphokines in soft agar. Ninety percent of the cases studied exhibit inhibition of tumor cell proliferation with BCG-or MDP-treated lymphocytes. The data suggest both BCG and MDP may enhance regional nodal lymphocyte tumor inhibition.

(Arch Otolaryngol 1985;111:465-468)

Author Affiliations
From the Departments of Otolaryngology (Dr Schuller and Ms Libby), Medicine (Dr Rinehart), and Physiologic Chemistry (Dr Milo), and the Comprehensive Cancer Center (Ms Koolemans-Beynen), Ohio State University College of Medicine, Columbus.

Footnotes
Accepted for publication Dec 12, 1984.

Read before the International Conference on Head and Neck Cancer, Baltimore, July 1984.

Reprint requests to Department of Otolaryngology, Ohio State University, 456 Clinic Dr, Columbus, OH 43229 (Dr Schuller).

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