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David E. Schuller, MD; James S. McCaughan, Jr, MD; Raymond P. Rock, MD

Arch Otolaryngol. 1985;111(6):351-355.

Abstract
• A group of 24 patients with recurrent and/or metastatic cancers were treated with photodynamic therapy using hematoporphyrin derivative (HpD) to study feasibility of this new technique. This experience demonstrated that photodynamic therapy is possible for head and neck cancer and that the toxic reactions and complications are minimal. The short durations of response in this group of patients most probably are a reflection of current lack of understanding about what represents maximal tolerable doses of HpD and frequencies of treatment.

(Arch Otolaryngol 1985;111:351-355)

Author Affiliations
From the Department of Otolaryngology, Grant Hospital and Ohio State University (Drs Schuller and Rock), and the Laser Medical Research Foundation and Laser Center, Grant Hospital (Dr McCaughan), Columbus.

Footnotes
Accepted for publication Nov 6, 1984.

Read before the International Conference on Head and Neck Cancer, Baltimore, July 23, 1984.

Reprint requests to Department of Otolaryngology, Ohio State University, 456 Clinic Dr, Columbus, OH 43229 (Dr Schuller).

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