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A Complication of High-Dose Cisplatin

Troy H. Guthrie, Jr, MD; Lawrence Gynther, MD

Arch Otolaryngol. 1985;111(5):344-345.

Abstract
• Acute, profound cisplatin-induced deafness has rarely been reported. Ototoxic reactions to cisplatin in the past have been subclinical, with most hearing loss occuring in the high-frequency range. A patient was treated with ultra-high-dose cisplatin who suffered acute profound deafness. Methods are suggested for preventing similar complications in other patients given cisplatin in high-dose ranges.

(Arch Otolaryngol 1985;111:344-345)

Author Affiliations
From the Medical College of Georgia, Augusta.

Footnotes
Accepted for publication Dec 20, 1984.

Reprint requests to Department of Hematology and Medical Oncology, Medical College of Georgia, Augusta, GA 30912 (Dr Guthrie).

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