This Article  • References  • Full text PDF  • Reply to article  • Send to a friend  • Save in My Folder  • Save to citation manager  • Permissions  Citing Articles  • Contact me when this article is cited  Related Content  • Similar articles in this journal  Social Bookmarking   What's this?

Ultrastructure and Immunohistochemistry

Richard J. Zarbo, MD, DMD; Andrew Ricci, Jr, MD; Pamela D. H. Kowalczyk, MD; Richard W. Cartun, MS; David R. Knibbs

Arch Otolaryngol. 1985;111(5):333-337.

Abstract
• To our knowledge, this is the first case of an intranasal monomorphic salivary gland adenoma (dermal analogue type) arising in a man exhibiting the salivary gland—skin adnexal tumor diathesis. Ultrastructurally, this tumor is composed of cells displaying squamous, secretory, luminal, and, very rarely, myoepithelial differentiation. Additionally, this is the first ultrastructural demonstration of intralobular Langerhans' cells in a dermal analogue tumor from any site. These Langerhans' cells can be demonstrated histologically by S-100 protein immunostaining. Epithelial tumor cells per se display no glial fibrillary acidic protein immunoreactivity, but rare epithelial cells stain faintly for S-100 protein. These findings seem to be distinct from pleomorphic adenoma and adenoid cystic carcinoma, the principal histologic differential diagnosis.

(Arch Otolaryngol 1985;111:333-337)

Author Affiliations
From the Department of Pathology, Hartford (Conn) Hospital.

Footnotes
Accepted for publication Nov 26, 1984.

Read in part before the annual meeting of the American Academy of Oral Pathology, Boston, May 7, 1984.

Reprint requests to Department of Pathology, Harper-Grace Hospitals, Detroit, MI 48201 (Dr Zarbo).

CiteULike    Connotea    Del.icio.us    Digg    Reddit    Technorati    Twitter     What's this?