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Yoshiro Yazawa, MD; John J. Shea, MD; Masaaki Kitahara, MD

Arch Otolaryngol. 1985;111(5):301-304.

Abstract
• There have been several reports of perisaccular fibrosis of the endolymphatic sac in some autopsied cases of Meniere's disease. We attempted to initiate perisaccular fibrosis of the sac in guinea pigs by injecting a small amount of 10% silver nitrate solution that cauterizes the tissue readily to produce scar, ie, fibrosis. Ninety-nine guinea pigs out of 108 (92%) that were treated with silver nitrate showed the endolymphatic hydrops in varied extent, from slight to profound. The extent of hydrops might depend on the extent of destruction of the sac following the cauterization. The lumen of the sac was sometimes occupied with dense fibrous connective tissue with deposition of black-silver particles in it. The silver nitrate injection method is an easy way to produce endolymphatic hydrops in guinea pigs.

(Arch Otolaryngol 1985;111:301-304)

Author Affiliations
From the Department of Otolaryngology, Shiga University of Medical Science, Otsu, Japan (Drs Yazawa and Kitahara), and the Shea Clinic and Deafness Foundation, Memphis (Dr Shea).

Footnotes
Accepted for publication Nov 16, 1984.

Reprint requests to Department of Otolaryngology, Shiga University of Medical Science, Seta, Otsu, Japan 520-21 (Dr Yazawa).

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ABSTRACT