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Hans Gustafsson, MD; Uno Kjörell, DDS; Bengt Carlsöö, MD

Arch Otolaryngol. 1985;111(2):99-105.

Abstract
• Oncocytomas and Warthin's tumors were studied ultrastructurally and with immunofluorescence microscopic techniques against cytokeratins, desmin, vimentin, and actin, the latter characterizing myoepithelial cells. The cell types were found within oncocytomas, one type packed with mitochondria and virtually without filaments, the other contained fewer mitochondria but large amounts of cytokeratins. In Warthin's tumors, all cells contained cytokeratins, the basal cell to a much higher degree. No tumor cells contained vimentin or desmin. Actin was found only close to the apical cell surface in the cylindrical cells in the Warthin's tumors and around the few acinar lumina found in the oncocytomas; thus, a myoepithelial origin of oncocytic tumors of salivary glands seems less plausible. The similarity in staining pattern, namely the pronounced dimorphism of both tumor types, indicates a common progenitor of oncocytomas and the epithelial component in adenolymphomas.

(Arch Otolaryngol 1985;111:99-105)

Author Affiliations
From the Departments of Otorhinolaryngology (Drs Gustafsson and Carlsöö), Histology and Cell Biology (Drs Gustafsson and Carlsöö), and Anatomy (Dr Kjörell), University of Ume (Sweden).

Footnotes
Accepted for publication Aug 28, 1984.

Reprint requests to Department of Otorhinolaryngology, University of Ume, S-901 87 Ume, Sweden (Dr Gustafsson).

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