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Hans Ikenberg, MD; Dieter Neumann-Haefelin, MD; Bertram Richthammer, MD; Wilhelm Wolfart, MD; Claus-Peter Adler, MD; Gerhard Bodo, PhD; Lutz Gissmann, PhD; Harald zur Hausen, MD

Arch Otolaryngol. 1985;111(2):96-98.

Abstract
• In biopsy specimens from a patient with tracheal and bronchial papillomatosis, human papillomavirus (HPV) type 11 DNA was identified. Treatment with leukocyte interferon was initiated, and the results of therapy was monitored by molecular hybridization of biopsy specimens with phosphorus 32-labeled HPV type 11 DNA after interferon application. There was no improvement of the clinical course, although two of five biopsy specimens showed a considerable reduction in the amount of HPV type 11. We discuss the reasons for the insufficient effect of therapy and propose molecular hybridization as an additional method for therapy control in viral diseases.

(Arch Otolaryngol 1985;111:96-98)

Author Affiliations
From the Deutsches Krebsforschungszentrum, Heidelberg (Drs Ikenberg, Gissmann, and zur Hausen), and the Institut für Virologie, Zentrum für Hygiene (Dr Neumann-Haefelin), Chirurgische Universitätsklinik, Abteilung Lungenchirurgie (Drs Richthammer and Wolfart), and the Institut fur Pathologie (Dr Adler), Universität Freiburg (Federal Republic of Germany); and the Ernst-Boehringer-Institut für Arzneimittelforschung, Vienna (Dr Bodo). Dr Ikenberg is now with the Universitätsfrauenklinik, Freiburg.

Footnotes
Accepted for publication Sept 5, 1984.

Reprint requests to Universitätsfrauenklinik, Hugstetterstr 55, D-7800 Freiburg, Federal Republic of Germany (Dr Ikenberg).

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