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Amino-oxyacetic Acid as a Palliative in Tinnitus
Hollis T. Reed, MD;
J. Meltzer, MAT;
Patricia Crews, MA;
Charles H. Norris, PhD;
Douglas B. Quine, PhD;
Paul S. Guth, PhD
Arch Otolaryngol. 1985;111(12):803-805.
Abstract
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• Amino-oxyacetic acid, previously shown to cause a reversible loss of hearing sensitivity and a reduction in endocochlear potential, was tried as a papillative in human tinnitus. Because the drug seemed to have a cochlear site of action, patients were selected for the study if their audiograms were indicative of cochlear lesions and if there was a reduction in tinnitus following intravenous lidocaine (lidocaine positive). Ten such patients received either 50 or 75 mg of amino-oxyacetic acid four times a day orally for one week or placebo administered in a random, crossover, double-blind design. Of these ten, three reported subjective lessening of tinnitus. One of those three and two others not reporting subjective lessening of tinnitus showed a substantial improvement in speech discrimination scores while receiving amino-oxyacetic acid but not placebo. One additional patient who did not receive lidocaine also reported a subjective lessening of tinnitus. Four patients who were lidocaine negative showed neither subjective nor objective improvement in tinnitus after treatment with amino-oxyacetic acid.
(Arch Otolaryngol 1985;111:803-805)
Author Affiliations
From the Departments of Otolaryngology (Drs Reed and Norris and Mss Meltzer and Crews) and Pharmacology (Drs Quine and Guth), Tulane University School of Medicine, New Orleans.
Footnotes
Accepted for publication March 20, 1985.
Reprint requests to Department of Pharmacology, Tulane University School of Medicine, 1430 Tulane Ave, New Orleans, LA 70112 (Dr Guth).
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